Pemphigoid

An event, such as sunburn or a reaction to a drug, can trigger the blisters, but it usually occurs spontaneously. It is not caused by an infection or allergy, cannot be passed from person to person and is not affected by diet or lifestyle. It is not hereditary so it cannot be passed on to your children.

Is pemphigoid hereditary?

No.

• A rash may be present for weeks before any blisters appear. The rash may be itchy and look like eczema or, more commonly, like the red weals of nettle rash (urticaria).
• Most commonly, pemphigoid causes red skin patches on which blisters can appear. Any part of the skin can be involved, but the most common sites for the blisters are the body folds, hands, feet and the skin on the abdomen (belly area). In severe cases, the blisters can occur all over the body or in the mouth. If pemphigoid blisters do appear in the mouth, gums or other moist areas (known as mucous membranes), you may be affected by a rare condition called mucous membrane pemphigoid – you must check with your doctor to confirm this.
• Blisters are firm and filled with a fluid. Most commonly, the fluid is clear but, in some people, it can be bloodstained. As more fluid builds up in them, the blisters become larger and tense, and eventually burst. The skin left behind can be sore. When the skin blisters heal, they do not leave scars but there might be skin colour changes seen after the inflammation has settled down.
• Roughly a quarter of patients with pemphigoid have blisters or sore areas in the mouth.

Images DermNetNZ.

Usually, the look of the rash is enough for your GP to make the diagnosis, but further investigations may be performed including a blood test or skin biopsies (under local anaesthetic).

Can pemphigoid be cured?

No. However, different treatments can control the condition well, rather than curing it completely. However, pemphigoid can often spontaneously resolve after one to five years.

Treatment has three aims – to stop new blisters,; to help heal the blisters that are already there; and to use the lowest possible dose of a medicine to control the condition and reduce the risk of side effects.

• The blister should be burst and dressed by a nurse to help relieve some of the pressure and discomfort. You can do this yourself once shown how to do this safely and hygienically.
• A steroid cream (such as clobetasol propionate also known as Dermovate® and Clobaderm®) are prescribed if the blisters appear in small areas. Oral steroids may be given if the blistering if extensive and creams are not enough. Steroid creams or ointments are much less likely to cause side effects than steroid tablets.
• Antibiotics called tetracyclines can also help reduce inflammation.
• A medicated mouthwash may be given if you have blisters in your mouth.
• For more extensive blistering, high doses of steroid tablets may be needed to get the pemphigoid under control. Some patients can come off their treatment gradually, usually after a few months; others will need to continue with lower doses for a number of years You may be given tablets to protect your bones (depending on your age, risk and length of steroid course) and an anti-acid tablet to protect your stomach lining.
• Other tablets that affect the immune system can be used at the same time as the steroid tablets. Examples of additional tablets that can be used in this way are azathioprine, mycophenolate mofetil and dapsone.

If you are on long term steroid tablets and suddenly cannot take them (e.g. if misplaced or you are vomiting) you should contact 111 or your GP urgently.